肋骨：粘液样纤维瘤？讨论病例【91360.软组织806】

刘伟

一公里生命
病例(形态)分享第523例
27 year old female with a relatively well circumscribed radioluscent rib lesion. Differential? Is IHC helpful? Is molecular testing helpful?



伊人一方
软骨粘液样纤维瘤


一公里生命
Diagnosis: Chondromyxoid Fibroma -Rare bone tumor (1% primary bone tumors); typically occurs in long bones but can involve flat bones -Lobulated architecture, central areas of chondromyxoid matrix and areas of peripheral condensation

2) of small stellate to spindled cells. Course calcifications (sometimes grungy like PMT) may be present, multinucleated giant cells and hemangioperycitic vessels. -IHC is unhelpful. No specific markers, like other cartilage lesions will be positive for S100, Sox10 and ERG
3) peripheral myofibroblastic/condensed areas may show increased SMA staining, and vessels will be highlighted by vascular markers 4) t(6;9)(q25;q22) and inv(6)(p25q13) described, recurrent GRM1 fusions play a role in the development.
原作者说
Normal phosphate levels. Did not do FGF23 but it would be negative

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