肺， SMARCA4-deficient thoracic neoplasm，讨论病例【91360，软组织589】

刘伟

一公里生命
Lobectomy for a primary lung mass. Histology shows a poorly differentiated malignant neoplasm. What is the differential diagnosis? Which stains would you consider?

周泉
CK，EMA，CD34.ERG，INI1，BRG1.SALL4.Syn，LCA，CGA，S100.NUT？

一公里生命
Morphological features include discohesive round cells with prominent nucleoli, brisk mitoses, and necrosis. IHC shows focal, weak keratin expression and loss of SMARCA4.
The diagnosis is SMARCA4-deficient thoracic neoplasm.
Originally thought to be sarcomas, SMARCA4-deficient thoracic tumors are now believed to be undifferentiated lung carcinomas based on clinical, pathological, and molecular features.

whyang315

excellent！