双相滑膜肉瘤？讨论病例【91360.软组织496】

刘伟

一公里生命
病例(形态)分享第308例
三无病例



一公里生命















一公里生命
Biphasic Synovial Sarcoma


❇️Tumor of deep soft tissues of extremities or head & neck
❇️Good prognosis if
- <20% poorly differentiated histology
- <5cm size (minute SS <1cm excellent prognosis)
- <10 mitosis in 1.7mm2
- no necrosis
- child
一公里生命
CK, EMA positive in epithelial > spindle cell comp
❇️TLE1 strong + but can also be seen in SFT (CD 34 neg in SS) & MPNST (more pleomorphism)
❇️CD99, BCL2 + but non-specific
❇️S100 + focal in 30% - pitfall with MPNST

一公里生命
Balanced reciprocal t(X;18)(p11;q11) where SS18 on chr 18 fuses with SSX genes (SSX1, SSX2 or SSX4) on X chr.

注：病例来自网络，版权归原作者仅供学习