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[讨论整理] 胃,Gastrointestinal Stromal Tumou讨论病例【91360,软组织635】

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 楼主| 发表于 2021-1-25 13:10:47 | 显示全部楼层 |阅读模式
病例信息
性别:未知年龄:0
临床诊断:
一般病史:
标本名称:
大体所见:

    一公里生命
    病例(形态)分享第593例
    胃,成人

    任俊奇
    平滑肌肉瘤?
    一公里生命
    Keratin-positive gastrointestinal stromal tumor of the stomach mimicking gastric carcinoma: diagnosis confirmed by c-kit mutation analysis
    Abstract
    In routine practice, gastrointestinal stromal tumor (GIST) can usually be identified with relative ease on the basis of a rather simple immunohistochemical panel besides its characteristic morphology. Still, serious differential diagnostic problems may arise because of the heterogeneity of these tumors in both morphologic appearance and clinical behavior. In our case, we present a metastatic, ulcerative, hemorrhagic GIST with epithelioid appearance, which displayed diffuse pan cytokeratin (AE1/AE3) positivity beside CD117 expression. As carcinomas may also be CD117-positive, definitive diagnosis was confirmed by the detection of a hexanucleotide deletion in the exon 11 of c-kit. This case demonstrates that although gastric carcinoma more commonly ulcerates or causes hemorrhage than GIST, keratin-positive GIST should also be considered from a differential diagnostic point of view. In these cases, c-kit mutation analysis may be necessary.

    Diagnosis:

    Gastrointestinal Stromal Tumour (GIST)

    微信图片_20210125130733.jpg

    微信图片_20210125130736.jpg

    微信图片_20210125130740.jpg

    微信图片_20210125130744.jpg

    微信图片_20210125130748.jpg
    DES

    微信图片_20210125130752.jpg
    Cam5.2

    微信图片_20210125130759.jpg

    CD117
    微信图片_20210125131013.jpg
    DOG/1
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    发表于 2021-2-14 17:28:43 | 显示全部楼层
    谢谢分享!
    本论坛为非盈利学术交流平台,资料均由网友上传,如涉及版权问题请及时联系管理员处理;所有讨论内容仅供公益交流,不代表本论坛立场。投诉邮箱:tougao@91360.com
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