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发表于 2019-1-4 17:32:41
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Seromucinous ovarian tumor A comparison with the rest of ovarian
epithelial tumors☆
Georgia Karpathiou a,⁎, Celine Chauleur b, Thomas Corsini b, Melany Venet a, Cyril Habougit a,
Freschia Honeyman a, Fabien Forest a, Michel Peoc'h a
a Department of Pathology, North Hospital, University Hospital of St-Etienne, France
b Department of Gynecology and Obstretics, North Hospital, University Hospital of St-Etienne, France
a r t i c l e i n f o a b s t r a c t
Background: Seromucinous ovarian tumors are rare and not adequately described in the literature and this is especially
true for seromucinous carcinomas.
Aimof the study: To describe histological and clinical features of these tumors in comparisonwith the rest of ovarian
epithelial tumors.
Materials and methods: Two hundred and forty one (241) ovarian tumors, borderline (n=92) or malignant (n=
149), treated surgically without neoadjuvant chemotherapy, were examined.
Results: Seromucinous borderline (SMBT) and malignant tumors (SMC) comprised 7.8% (n=7) and 4% (n=6)
of all borderline tumors and carcinomas, respectively, studied.Mean age of diagnosis was 63.2 and 68.3 years and
mean size was 6.4 cm and 12 cm for SMBT and SMC, respectively. Seromucinous tumors were associated with
endometriosis in 23.1% of the cases and they were bilateral in 30.8%. Microscopically, variety in cellular composition,
papillary architecture and development into thickwalled, occasionallymuscular, cystswere themain findings.
Medullary/paraovarian/tubal or deeply cortical localization was also characteristic. Stage predicted overall
and progression-free survival (p b 0.0001 and p = 0.03, respectively). Five-year survival was 62% for patients
with high grade serous carcinoma, 55% for seromucinous carcinoma, 100% for endometrioid carcinoma, 75%
for clear cell carcinoma, and 80% for patientswithmucinous carcinoma. Differenceswere not however statistically
significant.
Conclusion: Seromucinous tumors have unique features that support their classification as a different entity. Their
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