胃： SDH-B deficient epithelioid GIST.？讨论病例【91360.软组织812】

刘伟

一公里生命
病例(形态)分享第528例
Young male. Transgastric fine-needle biopsies of submucosal gastric mass. What are your thoughts and what IHC would you like to see?



伊人一方
首考上皮样GIST.除外NET


一公里生命
This was a SDH-B deficient epithelioid GIST.
→More likely to metastasize (LN/liver), but indolent despite advanced disease
→Invariably gastric
→Wild-type for KIT/PDGFRA (this case was)
→∴ less likely to respond to TKIs
→Consider Carney triad/Carney-Stratakis syndrome

注：病例来自网络，版权归原作者仅供学习