转移性肾髓质癌?Metastatic RCC with medullary phenotype?讨论病例【中华病理GU学组肾脏病理交流群病例53】

小王

孔祥田
20s F sternum bone bx. She has a big mass in left kidney.





















Gata3-, your Dx?

陈铌
肾髓质癌伴镰刀细胞贫血？

赵明
Metastatic RCC with medullary phenotype

孔祥田
@陈铌四川大学华西医院 @赵明 浙江省 why oct4 is positive?

赵明



肾髓质癌表达OCT3-4：潜在的诊断陷阱.pdf (542.91 KB, 下载次数: 0)

2018-5-11 15:02 上传

点击文件名下载附件

@孔祥田(Max)*Sacramento*CA]

胡桂明
如果病人有镰刀状贫血，就发：转移性肾髓质癌，若没有就发：Metastatic RCC with medullary phenotype，两者都有INI1缺失。

饶秋
同意以上意见，免疫表型是符合的。但组织结构因为是转移病灶，所以不好评估。

孔祥田
@赵明 浙江省 @胡桂明~郑州大学第二附属医院 @饶秋 南京总医院，群负责人 This patient has sickle cell trait you can see from the 40x power fields(last two H&E photos). This is a consult case and the submitted pathologist did extensive work up. Here is the summary. IHC: positive for panCK, ck7, Oct4, and pax8. Negative for INI1, sox10, CD34, cd20, cd30, ck20, gata3, ER, breast Mix(BRST2/mammaglobin), cd10, synaptophysin, sall4, and TTF-1. I called it “Metastatic renal medullary carcinoma associated with sickle cell trait”. Thanks for your discussion.